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  • br Conclusions br We have demonstrated the applicability

    2020-08-28


    5. Conclusions
    We have demonstrated the applicability of the multiplicative (re-lative) risk model to data from glycidol carcinogenicity studies. A good agreement between observed and predicted tumor incidence was shown in glycidol-exposed mice and rats, indicating a relative risk coefficient per internal dose that is approximately independent of tumor site, sex, and species. Further, internal dose measurements of the genotoxic 4u8C improve the accuracy of the risk estimation and enable a more reliable extrapolation between exposure doses and between spe-cies to a risk coefficient for humans.
    Acknowledgement
    We are thankful to Björn Platzack, Marie Eriksson, Camilla Bengtsson, Susanne von Mentzer-Andersson and Jenny Lindahl at Swetox, Södertälje, Sweden for excellent care and treatment of the animals in the metabolism studies. This work was supported the Swedish Research Council Formas (grant number 216-2012-1450) and by Stockholm University, Stockholm, Sweden. The animal metabolism studies were partly financed by the Department of Environmental Medicine (IMM), Karolinska Institute, Solna, Sweden.
    Appendix A. Supplementary data
    References
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